The Barbados allrounder is on her way back to the Caribbean to take part in the Caribbean Premier League and its 10-over warmup act, the 6ixty
Australia batter Erin Burns has been drafted in as a late replacement for Deandra Dottin by Manchester Originals.
Dottin signed off her participation in this year's Hundred with a bombastic half-century in Originals' defeat by Northern Superchargers at Headingley on Sunday.
The Barbados allrounder is on her way back to the Caribbean to take part in the Caribbean Premier League and its 10-over warmup act, the 6ixty. Dottin will represent Trinbago Knight Riders in both events.
Deandra Dottin has left Manchester Originals [Getty Images]
Dottin's prowess with bat and ball will be hard to replace but, in Burns, Manchester do have an able and experienced deputy.
The 34-year-old has been capped six times for her country but has featured regularly in the WBBL, with Hobart Hurricanes and Sydney Sixers.
A powerful top-order batter, she can also contribute offbreaks.
Dottin leaves the competition having made 147 runs at a strike rate of 181. She claimed four wickets.
Manchester Originals sit sixth in the table after returning one win from their first four matches. They are next due in action at Birmingham Phoenix on Sunday (August 28).