The 46-year-old was appointed to both roles in September 2019 but felt it would be difficult to occupy the positions going forward
Misbah-ul-Haq has stepped away from his position as Pakistan chief selector to focus on coaching the men's team.
The former skipper was appointed to both roles in September 2019 after an overhaul behind the scenes in the wake of a disastrous World Cup campaign.
But the 46-year-old will only occupy a single position going forward following an internal review. The PCB's new code of ethics, which attempts to resolve conflicts of interest, is understood to be central to the decision.
"I have thoroughly enjoyed the dual roles but after reviewing the past 12 months and looking ahead at the workload in the next 24 months of my tenure, it is appropriate that I invest and dedicate all my time, energy, and attention to one role from now on," said Misbah, whose replacement is expected to start on December 1.
"Coaching is my passion and my ultimate objective remains to contribute to the development of players and help the side achieve bigger successes.
"When I was appointed last year, I was offered the coaching role first and then given the option to also head the selection committee, which I had graciously accepted.
"I am grateful to the Pakistan Cricket Board for their understanding and for supporting my thought process."
Since taking on both roles, Pakistan have won seven of their 19 matches across all formats. Most recently they came away from the tour of England with a 1-0 Test series defeat and a tied T20 series.
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