Moeen's one over, the 13th, was dispatched for 21 runs as Babar Azam and Mohammad Rizwan chased down 200 with three balls and 10 wickets remaining
Moeen Ali has pinpointed his expensive over as the turning point in England's 10-wicket defeat to Pakistan in Karachi.
Opening pair Babar Azam and Mohammad Rizwan put on the fifth-highest partnership in men's T20I cricket to successfully chase 200 with three balls to spare, Azam finishing unbeaten on 110 off 66 and Rizwan 88 off 51.
Rizwan had earlier been handed a lifeline in the powerplay when Alex Hales put down a routine chance to dismiss the wicketkeeper on 23.
However, temporary captain Moeen believes bringing himself on to bowl the 13th over was "a gamble" which didn't come off. Pakistan headed into the final eight overs with 96 runs still required but dispatched the spinner for 21 runs – including three sixes – to bring the equation down to 75 off 42.
Babar Azam and Mohammad Rizwan overpowered England [Alex Davidson/Getty Images]
Moeen had earlier played a starring role with the bat for England, smashing 55 runs off 23 balls to carry his side to 199 for 5 at close.
"The momentum changed when I bowled my over," Moeen told Sky Sports after the match. "That really gave them belief and after that they were almost unstoppable.
"I felt like it was under control for most of it. I genuinely feel my over lost the game for us. that was a gamble on my part.
"I went to try and get a wicket, almost buy a wicket. Obviously it didn't work and that's when Pakistan really won the game.
"We dropped a big catch obviously. You can't afford to drop them and you can't afford to bowl an off-spinner to them at such a big time."
Praising Rizwan and Azam, he added: "They played really well tonight. I know they get a lot of stick for their strike rates but I believe their strike rates are very good and they are brilliant players. Today it was their day."