The west-country venue is the second major cricket ground in the UK to be used as a centre to administer jabs to the public
Gloucestershire's County Ground Bristol will stage part of the roll-out of vaccines for Covid-19 from Thursday (January 14).
It becomes the second major cricketing venue to be used to assist with the challenge of protecting the nation against the virus.
Lord's, home of MCC and Middlesex, was the first to be confirmed, with Kent's Canterbury ground expected to join the effort next week.
Nearby Ashton Gate, home of Championship football club Bristol City, is already being used as one of seven mass vaccination centres.
Lord's opens up as Covid-19 vaccination centre
Patients will receive their jabs in the Jessop Room on the ground floor of the Bristol Pavilion. Club's staff have volunteered to help with the roll-out.
"At one of the most testing times we have all faced, Gloucestershire cricket has been proud to partner with Gloucester Road Medical Centre to offer our facilities for vaccinations to those in our local community," said chief executive Will Brown.
"Following on from last autumn’s flu jabs, and at a time where the vast majority of our staff are working remotely, it is heartening to see our home and facilities being used to help combat COVID-19."