New batters will face the next delivery after a player is given out caught, in a rule first trialled during The Hundred. The raft of new regulations will be introduced from October 1, 2022
Using saliva to shine the ball will constitute ball-tampering as part of a fresh batch of rules passed by the MCC.
The Covid-19 pandemic saw the act outlawed on health and safety grounds.
There were fears it would nullify the influence of swing, with players forced to apply sweat in order to provoke movement in the air.
But research carried out by the MCC has concluded it makes little or no difference which is used.
As a result, the use of saliva has been banned, which also removes the grey areas around the use of sugary sweets.
Previously, breaches were treated as lapses, with the ball being subsequently sanitised, but going forward breaking the rules will be viewed in a different light.
Umpires currently sanitise balls which are mistakenly applied with saliva (Michael Stele/AFP/Getty Images)
The change to the regulations, along with a number of other alterations made by the game's lawmakers, will come into force from October 1, 2022.
MCC laws manager Fraser Stewart said: “Since the publication of the 2017 code of the laws of cricket, the game has changed in numerous ways.
"The second edition of that code, published in 2019, was mostly clarification and minor amendments, but the 2022 code makes some rather bigger changes, from the way we talk about cricket to the way it’s played.
"It is important that we announce these changes now as part of the club’s global commitment to the game, giving officials from all over the world the chance to learn under the new code ahead of the laws coming into force in October."
Elsewhere, the new batter will now face the next ball when reaching the crease after the preceding player has been out caught.
The change to the rules comes after a trial during The Hundred.
Sunil Narine hits out in the men's Hundred (Mike Hewitt/Getty Images)
Furthermore, there will be an alteration to how wides are determined. Due to the increasing trend of batters moving around the crease, stray deliveries will now be judged based on where they are standing when the ball is delivered, rather than from a conventional stance.
Replacement players for incidents such as concussion will now inherit any sanctions or dismissals of the individual they have come in for, in a new clause added to Law 1.
There are several alterations to the dead ball law, the most notable being if either side is disadvantaged by a person, animal or another object within the field of play The MCC explained: "From a pitch invader to a dog running onto the field, sometimes there is outside interference."
Illegal movement in the field, which was previously ruled a dead ball, will now also carry the penalty of five runs for the batting team.
The act of a batter leaving their ground before the bowler released the ball - which can result in a Mankad - has been moved in the rules from 'unfair play' to 'run-out'.
A statement released by the MCC, which serves as notice of the changes before they come into effect before the end of the year, adds "the changes are intended to shape the game of cricket as it should be played".